Balancing Act: Navigating GLP-1 Weight Loss and Nutrient Deficiencies 

According to the U.S. Food and Drug Administration (FDA), approximately 70% of American adults have obesity or overweight. Weight loss can be challenging for many people, even with a well-balanced diet and regular exercise. Over the past few years, GLP-1 medications (such as Ozempic, Mounjaro, Wegovy, etc.) have shown promising results in promoting fat loss and improving metabolic health. 

GLP-1 medications, short for glucagon-like peptide-1 receptor agonists, are a class of drugs designed to mimic the effects of a natural hormone in the body. They work by stimulating insulin secretion, reducing appetite, and slowing down stomach emptying, all of which contribute to weight loss. These medications have gained popularity due to their effectiveness in helping people achieve and maintain a healthy weight. 

On the other hand, individuals should be aware that the body’s nutrient needs may shift, leading to potential nutrient and vitamin deficiencies resulting in weight loss side effects if not addressed appropriately. 

In this blog, we will dive into the details of GLP-1 medications and their impact on weight loss, as well as the importance of vitamin supplementation and strategies to ensure optimal levels during your weight loss journey. By understanding the benefits and risks, we hope you can make more informed decisions to support your health goals effectively. 

GLP-1 Medications for Weight Loss

GLP-1 medications have emerged as a valuable tool for weight and fat loss, offering a new approach to addressing obesity and related metabolic conditions. These medications interact with the GLP-1 receptor, a key player in glucose metabolism and appetite regulation, and stimulate insulin secretion in response to elevated blood glucose levels. This enhanced insulin response helps to regulate blood sugar levels, reducing the risk of insulin resistance and type 2 diabetes. 

GLP-1 medications have also been found to suppress the appetite by acting on the hypothalamus, the part of the brain responsible for regulating hunger and satiety. By promoting feelings of fullness and reducing cravings, these medications can support calorie-restricted diets and help you make healthier food choices. 

Another benefit of GLP-1 medications is their impact on gastric motility, or the movement of food through the digestive system. By slowing down stomach emptying, these medications can delay the absorption of nutrients, leading to increased feelings of fullness and a reduction in food intake. 

It’s important to note that while GLP-1 medications offer significant benefits in terms of fat loss and metabolic health, they should be a part of your comprehensive weight loss strategy that includes diet modifications, physical activity, and behavioral interventions. At OnePeak Medical, our Fitness and Nutrition Advisors work closely with your Medical Provider to ensure adequate dosage and sustainable changes are incorporated into your long-term health goals. 

Overall, GLP-1 medications represent a promising option for those struggling with obesity. With OnePeak Medical’s holistic approach to weight loss, we can help people get off the “sick path” and back to optimal health and wellness. 

Vitamins for Weight Loss

Vitamins play a vital role in energy metabolism, cellular function, immunity, and overall well-being. Many essential nutrients that the body cannot produce on its own rely on dietary intake to maintain adequate levels. 

During weight loss journeys, there can be an increased risk of vitamin deficiencies due to changes in diet, nutrient absorption, and metabolic demands. Understanding the impact of these deficiencies is vital for optimizing weight loss and maintaining overall health. 

Vitamin B

B-vitamins play a key role in numerous metabolic processes essential for optimal health and well-being. They are an essential part of converting carbohydrates, fats, and proteins into usable energy for the body. During weight loss, when calorie intake is reduced, the body’s reliance on these nutrients for energy becomes even more important. 

Vitamin B Deficiency Symptoms

A deficiency in B-vitamins can manifest in various ways, including: 

  • Fatigue 
  • Weakness 
  • Nausea 
  • Irritability 
  • Cognitive impairment 

These symptoms can impact energy levels, mood, immunity, mental clarity, and overall well-being, potentially hindering progress in weight loss efforts. Additionally, specific B-vitamin deficiencies, such as Vitamin B12 deficiency, can lead to neurological complications if left untreated. 

Increasing B-Vitamins 

To mitigate the risk of B-vitamin deficiencies during weight loss, it’s important to focus on a nutrient-dense diet that includes a variety of vitamin-rich foods. Examples include: 

  • B1 (thiamine): Whole grains, legumes, nuts, and seeds. 
  • B2 (riboflavin): Dairy products, lean meats, leafy greens, and almonds. 
  • B3 (niacin): Chicken, fish, peanuts, and whole grains. 
  • B5 (pantothenic acid): Avocado, broccoli, eggs, and lentils. 
  • B6 (pyridoxine): Bananas, potatoes, poultry, and fortified cereals. 
  • B7 (biotin): Eggs, nuts, seeds, and sweet potatoes. 
  • B9 (folate): Leafy greens, legumes, citrus fruits, and fortified grains. 
  • B12 (cobalamin): Animal products (meat, fish, dairy), fortified plant-based foods, and supplements for those at risk of deficiency. 

At times, when diet is insufficient or absorption is compromised, nutritional supplementation can help bridge the gap and ensure adequate levels. At OnePeak Medical, we offer Vitamin B nutrient injections and all-natural supplements to help safeguard a sufficient daily intake of B-vitamins. 

Vitamin D

Vitamin D plays a crucial role for individuals taking GLP-1 medications or following a calorie-restricted diet. As you lose weight, you may experience changes in bone density that can be offset by adding additional Vitamin D. Moreover, Vitamin D has been linked to improved insulin sensitivity, which complements the weight loss benefits of GLP-1 medications. 

Vitamin D Deficiency Symptoms 

Low Vitamin D levels can manifest in various symptoms, especially during weight loss efforts. Common signs include: 

  • Fatigue 
  • Muscle weakness 
  • Bone pain or tenderness 
  • Frequent infections or illnesses 
  • Mood changes (depression and anxiety) 

These symptoms can exacerbate the challenges of weight loss, affecting energy levels and overall well-being. 

Increasing Vitamin D

To increase Vitamin D intake, individuals can incorporate certain foods into their diet, such as fatty fish (salmon, tuna, and mackerel), fortified dairy products (milk and yogurt), egg yolks, and fortified cereals. Sunlight exposure is also a natural way to boost Vitamin D levels, as the skin produces Vitamin D when exposed to UVB rays. However, be careful not to not overdo it. 

Supplementation may also be necessary for those with consistently low Vitamin D levels. Consulting with your OnePeak Medical Provider or Fitness and Nutrition Advisor for personalized guidance on Vitamin D supplementation is recommended to ensure optimal levels and support you during your weight loss journey. 


If you’re experiencing gastrointestinal side effects from the GLP-1 medication, adding probiotics into your diet may be beneficial. Probiotics can help replenish your gut with beneficial bacteria, potentially alleviating symptoms.  

How Do I Add More Probiotics?

To include more probiotics in your diet, consider consuming fermented foods like yogurt, kefir, sauerkraut, kimchi, and kombucha. Additionally, you can opt for probiotic supplements, but look for a high-quality product and consult with your OnePeak Medical Provider or Fitness and Nutrition Advisor if you have questions. 


In the pursuit of weight loss and improved metabolic health, understanding the connection between GLP-1 medications, vitamin deficiencies, and nutritional strategies is key to your overall success in achieving and maintaining a healthy weight. GLP-1 medications offer valuable benefits in promoting weight loss, reducing appetite, and enhancing metabolic function, making them a valuable tool in your weight loss journey. 

However, it’s essential to recognize the potential impact of these medications on nutrient status. Deficiencies can arise during weight loss efforts due to changes in dietary intake, nutrient absorption, and metabolic demands, leading to symptoms such as fatigue, weakness, and cognitive impairment. 

To mitigate the risk of vitamin deficiencies and optimize weight loss outcomes, individuals are encouraged to focus on nutrient-dense foods, such as whole grains, lean proteins, leafy greens, eggs, and nuts. Incorporating a variety of these foods into daily meals and snacks can help ensure adequate intake and support overall health. 

Additionally, supplementation can be beneficial for individuals with specific needs or challenges in meeting vitamin requirements through diet alone. High-quality supplements that provide the recommended daily allowance (RDA) of vitamins can complement dietary efforts and support optimal nutrient status. Stop by one of our fourteen clinics in Oregon or check out for a wide selection of all-natural supplements. All OnePeak Medical supplements are backed by an NSF certification – ensuring compliance with strict standards and procedures to meet high quality standards. Not only do our supplements meet FDA standards, but we provide additional third-party verification to guarantee the highest quality ingredients are being used. 

At OnePeak Medical, we approach weight loss as a holistic journey that includes not only medication and nutrition but also physical activity, stress management, and behavioral changes. By adopting a balanced and sustainable approach to weight loss, you can achieve lasting results and become one step closer to optimal health and wellness. 

Please consult with your OnePeak Medical Provider and Fitness and Nutrition Experts for personalized guidance and support throughout your weight loss process. We want to ensure you receive the necessary tools and resources to succeed in your health goals. Together, with informed choices and proactive strategies, we can embark on a path towards a healthier, more vibrant life.