Why Brilliant Women Need Optimal Brain Chemical Balance

So here’s the bottom line: without our brains, we wouldn’t be brilliant. Pretty obvious, right? We have to keep our brains working at the best possible level, or our ability to overachieve and stay in the game is just not going to happen. I want to enlighten you on what it takes to make your current stressed, “off-balance” brain GREAT and fully functional for years to come, keeping you performing at the highest level with the least amount of emotional and mental breakdowns.

8 ways that your stress is likely making your brain sick:

1. Stress depletes precious brain chemicals like serotonin and dopamine, causing depression and anxiety. Serotonin is the happy brain chemical that also plays a role in mood, learning, appetite, and sleep. Low serotonin is directly related to depression and anxiety and low dopamine causes a lack of zest, enthusiasm, and motivation for life and is the primary factor in addictions.

2. Stress halts the production of new brain cells, which explains why when we are overly stressed we don’t always think clearly or act in our best interests. Brain-derived neurotrophic factor (BDNF) is a protein that’s essential for keeping brain cells healthy, but high-stress cortisol production or stress hormone imbalances, reduce the production of BDNF, resulting in a halted production of new brain cells. The good news is that putting a stop to this imbalance means that yes, as you age, you can still make new, healthy brain cells (thank goodness!)

3. Chronic stress creates brain fog and emotional instability. Memory problems and a lack of concentration and focus are the hallmarks of chronic stress. Research clearly shows that chronic high stress causes electrical signals in the brain to be delayed or compromised, leaving us wondering why we walked into the bathroom only seconds after we knew we had to go.

4. Stress increases the radical damage in our brain. With high stress, free radicals (killer molecules) are made in surplus, which can cause normal healthy brain cells to rupture and die. If this is coupled with lack of sleep, poor diet, and excessive nutrient deficiencies, the free radical formation increases even more.

5. Stress makes your brain small. Yes, you heard that right. Research continues to show that high stress halts the making of new brain cells and neuronal pathways in the brain. Stress literally shrinks areas like the hippocampus (an area important for memory, and emotions) and the pre-frontal cortex (an area important for decision making and impulsive behavior…. AKA “shopping therapy.”)

6. Stress increases the chances you will have Alzheimer’s and dementia. 1 in 3 U.S. seniors will die with Alzheimer’s or some form of dementia. So we should be careful what we do to our brains to keep them protected.

7. Stress can lead to a toxic waste site in the brain. Every cell in our body is sensitive to toxins, but the brain is on the top of the list when it comes to sensitivity. We have a brain filter that normally keeps us safe, but when this barrier is compromised with stress causing it to be “leaky,” it lets in pathogens, poisons like heavy metals, chemicals, and other toxins we are exposed to.

8. Stress causes the brain to become inflamed. There are special cells in the brain called microglia that protect the brain from infection and toxins, essentially they are part of the brain’s immune system. Unfortunately, with high, relentless stress, the over-reacting of these microglia produces inflammation. This inflammation is part of the depression process as inflammation seems to have a role in all areas of disease in the body.

While we are on the subject of preserving the brain, I must talk about the connection between stress and alcohol and the effect on the brain.

The Alcohol/Stress Connection

With stress comes some level of anxiety, which, as many of us know all too well, alcohol easily manages. Alcohol increases the effects of GABA in the brain, creating a sense of calmness. What this means for you is that your thought, speech, and movements are slowed down, and the more you drink the more of these effects you’ll feel (hence the stumbling around, falling over chairs, and other clumsy things drunk people do). But here’s the twist: Alcohol also increases the release of dopamine in your brain’s “reward center.” The effect is that you keep drinking to get more dopamine release, but at the same time you’re altering other brain chemicals that are just enhancing your feelings of depression.


The focus should be on protecting our brain because without this precious, valuable, and irreplaceable organ we would be totally screwed. Keeping our brain chemicals in check and the neurotransmitters balanced is the goal for optimal concentration, memory, mood, and focus. Habituating on anything that alters the brain in a negative way is the fast pass to long-term problems that often are not reversible.

Originally published April 2019 in Thrive Global